On May 21, 1990, the AIDS Coalition to Unleash Power (ACT UP) stormed the DC campus of the National Institutes of Health to protest the lack of available drugs to treat AIDS. From his office, Dr. Anthony Fauci watches as the activists march around his building, chanting and shouting for his resignation. Meanwhile, a young gay filmmaker captures the events of the protest while attempting to deliver an important package to Fauci. As tensions rise and the demonstrations threaten to upend the scientists' work, Dr. Fauci is forced to reckon with his power and privilege.